Applicability of the pseudo-steady state assumption to the irreversible Michaelis-Menten reaction.
نویسندگان
چکیده
منابع مشابه
On the Dynamics of the Irreversible Michaelis-menten Reaction Mechanism
The mass action kinetic model of the irreversible Michael&Menten reaction mechanism is mathematically intractable: an explicit analytical solution cannot be obtained. This difficulty is overcome by applying simplifying kinetic assumptions but a full understanding of their dynamic implications and applicability is not readily available. This paper shows how simple modal analysis can provide both...
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It is shown here that a suitable form for estimation and inference using the Michaelis-Menten [(1913) Biochem Z. 49, 333-369] model for simple enzymic reactions is one in which the two parameters appear in the denominator of the equation. In this form, convergence to the least-squares estimates using the Gauss-Newton method [see Kennedy & Gentle (1980) Statistical Computing, Marcel Dekker, New ...
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We study chemical reactions with complex mechanisms under two assumptions: (i) intermediates are present in small amounts (this is the quasi-steady-state hypothesis or QSS) and (ii) they are in equilibrium relations with substrates (this is the quasiequilibrium hypothesis or QE). Under these assumptions, we prove the generalized mass action law together with the basic relations between kinetic ...
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ژورنال
عنوان ژورنال: JOURNAL OF CHEMICAL ENGINEERING OF JAPAN
سال: 1988
ISSN: 0021-9592,1881-1299
DOI: 10.1252/jcej.21.267